Michael D. West - Aging Will Be Cured
This guy says that the cure for aging is not too far off.
iDr. Allen is the Co-Founder and CEO of Elevian, a Harvard spinout developing medicines to cure aging. Elevian’s scientific founders, working at Harvard University, discovered natural proteins that regulate aging. One example, GDF11, a “young blood” factor, broadly stimulates repair of age-related damage. When provided to aging animals, GDF11 stimulates regeneration of heart, brain, muscle and other tissues, reversing age-related diseases
However, as we age, our cells are exposed to environmental factors and are subject to negative changes in their genomes through epigenetic mechanisms. These alterations accumulate over time and are strongly correlated with the decline observed in aging cells.
In this study researchers used the technique of partial cellular reprogramming to reset epigenetic alterations that occur in cells during aging, thus restoring youthful function in mice.To achieve this, they used just three reprogramming factors, Oct4, Sox2, and Klf4, to reverse age-related epigenetic markers and rejuvenate the old cells in the eyes of mice. The approach was able to regenerate the eyes of mice suffering from age- or injury-induced blindness by encouraging the cells to revert to a more youthful level of function and thus regenerative capacity.
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